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OpportunityAnalyzer: Acromegaly and Gigantism-Opportunity Analysis and Forecast to 2018
Publication Date Dec 2014
Product Type Report
Pages 161
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GlobalData estimates the 2013 sales for acromegaly and gigantism at approximately $588m across the 6MM covered in this report. The market will grow moderately at a CAGR of 3.74% during the five year forecast period, generating sales of approximately $707m at the end of 2018. Growing at a CAGR of 4.58% and generating around 68% of global sales in 2018, the US market will experience twice the rate of growth of the 5EU market. Two major trends are visible among the pipeline drugs and research and development (R&D) strategies employed by companies in this chronic disease space – a focus towards the treatment of refractory patients and the improvement of drug delivery mechanisms to increase patient convenience.
Scope

Overview of acromegaly and gigantism, including epidemiology, etiology, pathophysiology, symptoms, diagnosis, and treatment guidelines.

Annualized acromegaly and gigantism therapeutics market revenue, annual cost of therapy and treatment usage pattern data from 2013 and forecast for five years to 2018.

Key topics covered include strategic competitor assessment, market characterization, unmet needs, clinical trial mapping and implications for the acromegaly and gigantism therapeutics market.

Pipeline analysis: comprehensive data split across different phases, emerging novel trends under development, and detailed analysis of late-stage pipeline drugs.

Analysis of the current and future market competition in the global acromegaly and gigantism therapeutics market. Insightful review of the key industry drivers, restraints and challenges. Each trend is independently researched to provide qualitative analysis of its implications.


Key Questions Answered

    Although the standard treatments are effective in most patients, a growing number of patients are being discovered who remain uncontrolled by current therapy. Treatment of this patient segment presents a major unmet need in this market. There are other prominent unmet needs highlighted by the Key Opinion Leaders (KOLs). What are these? Will the pipeline drugs fulfil these unmet needs of the market?
    The five-year forecast period will mark the patent expirations of the major branded drugs in this market and the launch of three pipeline agents. How will the sales of the existing drugs be impacted? Which of the pipeline drugs will have the highest peak sales at the highest CAGR, and why?
    What are the major R&D strategies employed by companies in this disease space? What do KOLs think of these strategies? What are other opportunities for new entrants seeking to enter this market?


Key Findings

    One of the main drivers of the acromegaly and gigantism market during the forecast period will be the increased use of somatostatin analogs with better administration or dosing regimens; due to the recent focus on improving patient convenience for this chronic disease area.
    Another strong driver will be the treatment of refractory patient segments, which will lead to an overall increase in the drug treatment rate.
    Greater disease awareness and management of comorbidities are two of the biggest unmet needs in this market.
    Variation in clinical trial methodologies have hindered direct comparison of drug efficacy rates. Trial design needs to be improved by incorporating more randomized, head-to-head, prospective studies.
    The dominant trend among the pipeline drugs is towards development of novel drug delivery methods, rather than the exploration of new mechanisms of action.



Key Benefits

    Develop and design your in-licensing and out-licensing strategies through a review of pipeline products and technologies, and by identifying the companies with the most robust pipeline. Additionally a list of acquisition targets included in the pipeline product company list.
    Develop business strategies by understanding the trends shaping and driving the acromegaly and gigantism therapeutics market.
    Drive revenues by understanding the key trends, innovative products and technologies, market segments, and companies likely to impact the acromegaly and gigantism therapeutics market in future.
    Formulate effective sales and marketing strategies by understanding the competitive landscape and by analysing the performance of various competitors.
    Identify emerging players with potentially strong product portfolios and create effective counter-strategies to gain a competitive advantage.
    Track drug sales in the 6MM acromegaly and gigantism therapeutics market from 2013-2018.
    Organize your sales and marketing efforts by identifying the market categories and segments that present maximum opportunities for consolidations, investments and strategic partnerships.


List of Companies

    Novartis
    Ipsen
    Pfizer
    Chiasma
    Antisense Therapeutics
    Isis
    Camurus
    Roche
    Ambrilia
    Endo
    Aspireo
    Peptron
    Glide Pharma


List Of Tables

Table 1: Risk Factors and Comorbidities for Acromegaly and Gigantism

Table 2: Summary of the Global Reported Cases and Estimated Prevalence of Acromegaly

Table 3: Global Consensus Criteria for the Diagnosis and Cure of Acromegaly

Table 4: Sources of Acromegaly and Gigantism Prevalence Data in the 6MM

Table 5: Sources of Macroadenoma, Microadenoma, and Surgery Data in the 6MM

Table 6: 6MM, Diagnosed Prevalent Cases of Acromegaly, Both Sexes, Ages =15 Years, N, 2013–2023

Table 7: 6MM, Age-Specific Diagnosed Prevalent Cases of Acromegaly, Both Sexes, N (Row %), 2013

Table 8: 6MM, Sex-Specific Diagnosed Prevalent Cases of Acromegaly, Ages =15 Years, N (Row %), 2013

Table 9: 6MM, Diagnosed Prevalent Cases of Gigantism, Both Sexes, All Ages, N, 2013–2023

Table 10: 6MM, Age-Specific Diagnosed Prevalent Cases of Gigantism, Both Sexes, N (Row %), 2013

Table 11: 6MM, Sex-Specific Diagnosed Prevalent Cases of Gigantism, All Ages, N (Row %), 2013

Table 12: Leading Treatments for Acromegaly

Table 13: Comparative Assessment of Leading Pharmacological Drug Treatments for Acromegaly

Table 14: Product Profile – Sandostatin SC and Sandostatin LAR Depot

Table 15: Sandostatin LAR Depot SWOT Analysis, 2014

Table 16: Product Profile – Somatuline LA and Somatuline Depot

Table 17: Somatuline Depot SWOT Analysis, 2014

Table 18: Product Profile – Somavert

Table 19: Somavert SWOT Analysis, 2014

Table 20: Unmet Needs in Acromegaly

Table 21: Examples of Pivotal Trials for Approved Treatments for Acromegaly

Table 22: Acromegaly – Late-Stage Pipeline, 2014

Table 23: Product Profile – Signifor LAR

Table 24: Signifor LAR SWOT Analysis, 2014

Table 25: Product Profile – Oral Octreotide

Table 26: Oral Octreotide SWOT Analysis, 2014

Table 27: Product Profile – ATL1103

Table 28: ATL1103 SWOT Analysis, 2014

Table 29: Early-Stage Pipeline Products in Acromegaly

Table 30: Clinical Benchmark of Signifor LAR and Oral Octreotide

Table 31: Clinical Benchmark of ATL1103

Table 32: Commercial Benchmark of Signifor LAR and Oral Octreotide

Table 33: Commercial Benchmark of ATL1103

Table 34: Top-Line Sales Forecasts ($m) for Acromegaly and Gigantism, 2013–2018

Table 35: Key Events Impacting Sales for Acromegaly and Gigantism, 2013–2018

Table 36: Acromegaly and Gigantism Market – Drivers and Barriers, 2013–2018

Table 37: Key Launch Dates

Table 38: Key Patent Expiries
List Of Figures

Figure 1: Overview of GH/IGF-1 Pathway and Targets of Medical Therapy for Acromegaly and Gigantism

Figure 2: 6MM, Diagnosed Prevalent Cases of Acromegaly, Both Sexes, Ages =15 Years, N, 2013–2023

Figure 3: 6MM, Age-Specific Diagnosed Prevalent Cases of Acromegaly, Both Sexes, Ages =15 Years, N, 2013

Figure 4: 6MM, Sex-Specific Diagnosed Prevalent Cases of Acromegaly, Ages =15 Years, N, 2013

Figure 5: 6MM, Age-Standardized Diagnosed Prevalence of Acromegaly (Cases per Million Population), Ages =15 Years, by Sex, 2013

Figure 6: 6MM, Diagnosed Prevalent Cases of Gigantism, Both Sexes, All Ages, N, 2013–2023

Figure 7: 6MM, Age-Specific Diagnosed Prevalent Cases of Gigantism, Both Sexes, All Ages, N, 2013

Figure 8: 6MM, Sex-Specific Diagnosed Prevalent Cases of Gigantism, All Ages, N, 2013

Figure 9: 6MM, Age-Standardized Diagnosed Prevalence of Gigantism (Cases per Million Population), All Ages, by Sex, 2013

Figure 10: 6MM, Diagnosed Prevalent Cases of Acromegaly (Ages =15 Years) and Gigantism (All Ages) with Macroadenomas, Both Sexes, N, 2013 and 2023

Figure 11: 6MM, Diagnosed Prevalent Cases of Acromegaly (Ages =15 Years) and Gigantism (All Ages) with Microadenomas, Both Sexes, N, 2013 and 2023

Figure 12: 6MM, Diagnosed Prevalent Cases of Acromegaly (Ages =15 Years) and Gigantism (All Ages) Receiving Any Surgical Treatment, Both Sexes, N, 2013 and 2023

Figure 13: Acromegaly Treatment Management

Figure 14: Pharmacological Therapy Management in Acromegaly

Figure 15: Competitive Assessment of Signifor LAR and Oral Octreotide, 2013–2018

Figure 16: Competitive Assessment of ATL1103, 2013–2018

Figure 17: Sales for the Acromegaly and Gigantism Market in the US and 5EU, 2013–2018

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